Prostate specific antigen staining intensity in prostatic adenocarcinoma correlates with serum prostate specific antigen , Bandar Abbas, Iran

Introduction: Prostatic adenocarcinoma is one the most common malignances and the second cause of death in males due to cancer. Prostate Specific Antigen (PZSA) serum level is the first marker to screen such patients. We aimed in this study, to assess the intensity of prostatic adenocarcinoma tissue staining with PSA staining method. Methods: In this corss-sectional study, prostatic adenocarcinoma patients referred to pathology department of Shahid Mohammadi hospital, Bandar Abbas, during 2009-2010, were investigated. The samples were first stained with H&E staining. If adenocarcinoma was confirmed then PSA staining with IHC method was carried put. Normal prostate tissue and negative control with non granular tissue and non-grander tissue were considered as positive and negative controls, respectively. Collected data was analyzed with SPSS 16 , using descriptive methods and Chi-square test. Results: Mean age of the patients was 73.63±10.70, varying from 54 to 91 years. Grade of the tumors varied from 2 to 10, where the most frequent grade was 7. Results showed that as the degree of PSA staining decreased, serum PSA level increased (P=0.017). Conclusion: Results demonstrated that the intensity of PSA staining with IHC has a reverse correlation with serum PSA level, whereas higher gleasons grading associated with increased PSA serum levels.